(AGENPARL) – NEW HAVEN, CONNECTICUT (USA) sab 25 giugno 2022

Angelique Bordey, whose research explores how a mutated, dysfunctional protein will lead to abnormal brain formation and function, was recently appointed the Rothberg Professor of Neurosurgery, effective immediately.

She is also professor of cellular & molecular physiology at Yale School of Medicine.

Bordey received her Ph.D. in neuroscience from Université Louis-Pasteur in Strasbourg, France.

Her research lab is focused on the mechanistic Target of Rapamycin (mTOR), which is a converging point in cell signaling, or a sort of intracellular hub that receives signals from extracellular ligands and controls diverse intracellular routes. Importantly, mTOR is dysregulated in many neurological disorders. These disorders, which are referred to as mTORopathies, include (but are not limited to) Tuberous Sclerosis Complex (TSC), autism, Alzheimer’s disease, and schizophrenia. Her team has focused on TSC to better understand the circuit basis of epilepsy and autism. Specifically, they are working to understand how a circuit is formed from neural stem cells to circuit formation in health and in developmental mTORopathies; how to prevent brain malformations and associated neurological symptoms in TSC and other developmental mTORopathies; and the molecular basis of neurological dysfunctions in TSC.

Bordey is an active participant in teaching and training of graduate and medical students at Yale School of Medicine. She is an editor for several journals and on the advisory board of CURE epilepsy and the TSC Alliance preclinical consortium. She has served as a permanent member on several grant review committees and National Institutes of Health study sections. She is also a McKnight awardee and holds several federal and foundation grants as well as patents for the treatment of epilepsy.

Fonte/Source: https://news.yale.edu/2022/06/24/angelique-bordey-named-rothberg-professor-neurosurgery