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Monday, 22 December 2025
SITUATION REPORT
Multi-country outbreak of mpox, External situation report #61 – 22 December
[https://www.who.int/publications/m/item/multi-country-outbreak-of-mpox–external-situation-report–61—22-december-2025]
Overview
This is the 61th situation report for the multi-country outbreak of mpox, which provides details on the global epidemiological situation for mpox, including an update on the epidemiological situation with data on the global situation as of 30 November 2025, in Africa as of 14 December and the operational response updates as of 17 December 2025.
Highlights
• All clades of monkeypox virus (MPXV) continue to circulate. Unless mpox outbreaks are rapidly contained and human-to-human transmission is interrupted, there is a risk of sustained community transmission.
• In November 2025, 48 countries across all WHO regions reported a total of 2150 new confirmed mpox cases, including five deaths (case fatality ratio [CFR] 0.2%). About 68% of these cases were reported in the African Region. Four regions observed a decline in confirmed cases in November, compared to October 2025, while the European and Western Pacific regions reported more cases than the previous month.
• Nineteen countries in Africa reported active transmission of mpox in the last six weeks (2 November– 14 December 2025), with 1435 confirmed cases, including seven deaths (CFR 0.5%). Countries reporting the highest number of cases in this period are the Democratic Republic of the Congo, Guinea, Liberia, Kenya and Ghana; while case reports in Liberia still show indications of a rise, weekly case counts in the other countries have been declining in recent weeks.
• Romania has reported detection of clade Ib MPXV for the first time, in a case confirmed in August 2025.
• Outside Africa, community transmission of clade Ib MPXV continues in Spain and in the Netherlands. • In the Democratic Republic of the Congo, mpox transmission continues across multiple provinces with cocirculation of clades Ia and Ib MPXV, heterogeneous subnational trends and declining access to testing of suspected cases.
• The United Kingdom of Great Britain and Northern Ireland has reported a new travel-linked case of mpox with detection of a recombinant MPXV strain containing genetic elements of both clade Ib and clade IIb MPXV. The extent of circulation of the recombinant strain remains unknown.
• WHO assesses the ongoing public health risk to be moderate for men who have sex with men with new or multiple partners, sex workers and others with multiple partners who may be at risk, and low for the general population with no specific risk factors, continues close monitoring of the situation, and emphases the importance of maintaining surveillance and response capacity, including genomic sequencing notably in locations where multiple MPXV strains co-circulate
Read the full report: https://www.who.int/publications/m/item/multi-country-outbreak-of-mpox–external-situation-report–61—22-december-2025
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