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Thursday 9 August 2023
SARS COV2 variant EG.5: Initial Risk Evaluation
Full report: [https://bit.ly/3OrMcfZ]
More information on tracking variants: Tracking SARS-CoV-2 variants (who.int) [https://www.who.int/activities/tracking-SARS-CoV-2-variants]
As of 7 August 2023, 7354 sequences of Omicron EG.5 have been submitted to GISAID [http://www.gisaid.org/] from 51 countries. The largest portion of EG.5 sequences are from China (30.6%, 2247 sequences). The other countries with at least 100 sequences are the United States of America (18.4%, 1356 sequences), the Republic of Korea (14.1%, 1040 sequences), Japan (11.1%, 814 sequences), Canada (5.3%, 392 sequences), Australia (2.1%, 158 sequences), Singapore (2.1%, 154 sequences), the United Kingdom (2.0%, 150 sequences), France (1.6%,119 sequences), Portugal (1.6%, 115 sequences), and Spain (1.5%, 107 sequences).
Globally, there has been a steady increase in the proportion of EG.5 reported. During epidemiological week 29 (17 to 23 July 2023), the global prevalence of EG.5 was 17.4%. This is a notable rise from the data reported four weeks prior (week 25, 19 to 25 June 2023), when the global prevalence of EG.5 was 7.6%.
Based on the available evidence, the public health risk posed by EG.5 is evaluated as low at the global level, aligning with the risk associated with XBB.1.16 and the other currently circulating VOIs (see risk evaluation table below). While EG.5 has shown increased prevalence, growth advantage, and immune escape properties, there have been no reported changes in disease severity to date. While concurrent increases in the proportion of EG.5 and COVID-19 hospitalizations (lower than previous waves) have been observed in countries such as Japan and the Republic of Korea, no associations have been made between these hospitalizations and EG.5. However, due to its growth advantage and immune escape characteristics, EG.5 may cause a rise in case incidence and become dominant in some countries or even globally.
WHO and its Technical Advisory Group on SARS-CoV-2 Evolution (TAG-VE) continue to recommend that Member States prioritize specific actions to better address uncertainties relating to antibody escape and severity of EG.5. The suggested timelines are estimates and will vary from one country to another based on national capacities:
• Share information on the growth advantage of EG.5 in your country and/or provide sequence information (1-4 weeks).
• Conduct neutralization assays using human sera, representative of the affected community(ies), and EG.5 live virus isolates (2-4 weeks, see table below for the results from previously conducted).
• Perform a comparative evaluation to detect changes in rolling or ad hoc indicators of severity (4-12 weeks, see table below for the results from previously conducted studies).
The WHO and its Technical Advisory Group on COVID-19 Vaccine Composition (TAG-CO-VAC) continue to regularly assess the impact of variants on the performance of COVID-19 vaccines to inform decisions on updates to vaccine composition.(2)
The risk evaluation below is based on currently available evidence and will be revised regularly as more evidence and data from additional countries become available.
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