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NUCLEAR-TARGETED NANOCARRIERS BASED ON PH-SENSITIVE AMPHIPHILES FOR ENHANCED GNA002 DELIVERY AND CHEMOTHERAPY

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 25 gennaio 2021 GNA002, a novel EZH2 inhibitor, exhibits significant anticancer efficiency in solid malignant tumor therapy; however, its poor water solubility and low enrichment at tumor sites limit its clinical application and translation. In this study, an original pH-sensitive nanocarrier (cyclo (RGDyCSH) (cRGD)-poly......
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OBESITY MAY HELP TUMORS SURVIVE AND GROW, MOUSE STUDY SUGGESTS

Redazione
(AGENPARL) – BETHESDA (MARYLAND), sab 23 gennaio 2021 January 22, 2021, by NCI Staff Obesity may render T cells (green) around tumors less powerful by causing them to alter how they generate and use energy, a new study suggests. Credit: PLOS Biology. Feb 2004. doi: 10.1371/journal.pbio.. CC BY 4.0. Obesity......
Agenparl English Educazione Scienza e Tecnologia Social Network

NANOMEDICINE-BASED CANCER IMMUNOTHERAPY BY REPROGRAMMING TUMOR-ASSOCIATED MACROPHAGES

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), ven 22 gennaio 2021 The tumor microenvironment (TME) is a complex composed of tumor extracellular matrix, fibroblasts, blood vessels, and immune cells, promoting the occurrence and development of tumors by secreting a variety of growth factors, hydrolase, and inflammatory factors. Tumor-associated macrophages (TAMs) constitute the......
Agenparl English Educazione Salute Scienza e Tecnologia Social Network

NEW APPROACH EMERGES TO BETTER CLASSIFY, TREAT BRAIN TUMORS

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), mar 19 gennaio 2021 IMAGE: Dr. Jin-Xiong She and MD/PhD student Paul Tran. view more  Credit: Kim Ratliff, Augusta University Photographer AUGUSTA, Ga. (Jan. 19, 2021) – A look at RNA tells us what our genes are telling our cells to do, and scientists say looking directly......
Agenparl English Educazione Scienza e Tecnologia Social Network

BIFUNCTIONAL SCAFFOLDS OF HYDROXYAPATITE/POLY(DOPAMINE)/CARBOXYMETHYL CHITOSAN WITH OSTEOGENESIS AND ANTI-OSTEOSARCOMA EFFECT

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 18 gennaio 2021 The bifunctional tissue engineering scaffold with anti-tumor and bone repair property is promising for the therapy of bone tumor where large bone defect often occurred. In this study, hydroxyapatite (HA), poly(dopamine) (PDA) and carboxymethyl chitosan (CMCS) composite scaffolds were prepared by......
Agenparl English Educazione Scienza e Tecnologia Social Network

SELF-ASSEMBLY OF HYALURONIC ACID-MEDIATED TUMOR-TARGETING THERANOSTICS NANOPARTICLES

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), sab 16 gennaio 2021 Theranostic nanoparticle (NP) has emerged as a promising strategy for cancer diagnosis and treatment. Manganese dioxide (MnO2)-based NPs are potential contrast agents with excellent paramagnetic property and biocompatibility, endowing them with satisfactory magnetic resonance imaging (MRI) effect and biological safety. Recently,......
Agenparl English Educazione Salute Scienza e Tecnologia Social Network

CANCER MODELS CREATED BY MECHANICAL ENGINEERS OFFER NEW INSIGHT INTO TUMOR GROWTH

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), ven 15 gennaio 2021 (Rensselaer Polytechnic Institute) In research published today in Integrative Biology, a team of engineers from Rensselaer developed an in vitro — in the lab — lymphatic vessel model to study the growth of tumor emboli, collections of tumor cells within vessels that......
Agenparl English Educazione Scienza e Tecnologia Social Network

UCPS/ZN2GEO4:MN2+/G-C3N4 HETEROJUNCTION ENGINEERED INJECTABLE THERMOSENSITIVE HYDROGEL FOR OXYGEN INDEPENDENT BREAST CANCER NEOADJUVANT PHOTODYNAMIC THERAPY

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mer 13 gennaio 2021 Neoadjuvant chemotherapy of breast cancer can provide an opportunity of surgery for patients with large tumor mass or increase the rate of breast conserving. However, some patients are not sensitive to chemotherapeutic drugs, therefore it may cause them to miss the......
Agenparl English Educazione Salute Scienza e Tecnologia Social Network

DAMON RUNYON CANCER RESEARCH FOUNDATION AWARDS $2.65M TO INNOVATIVE SCIENTISTS

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), mar 12 gennaio 2021 The Damon Runyon Cancer Research Foundation announced that seven scientists with novel approaches to fighting cancer have been named 2021 recipients of the Damon Runyon-Rachleff Innovation Award. Five initial grants of $400,000 over two years were awarded to early career scientists whose......
Agenparl English Educazione Scienza e Tecnologia Social Network

A 3D PRINTED IN VITRO BONE MODEL FOR THE ASSESSMENT OF MOLECULAR AND CELLULAR CUES IN METASTATIC NEUROBLASTOMA

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mar 12 gennaio 2021 Metastasis is a complex and multifactorial process highly dependent on the interaction between disseminated tumor cells and the pre-metastatic niche. The metastatic sites detected in the bone of patients affected by neuroblastoma (NB), a malignancy of the developing sympathetic nervous system,......

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