Agenparl

tumor

Agenparl English Educazione Scienza e Tecnologia Social Network

DIAGNOSIS OF CANCER AT EARLY STAGES BASED ON THE MULTIPLEX DETECTION OF TUMOR MARKERS USING METAL NANOCLUSTERS

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mar 22 settembre 2020 Traditional cancer diagnosis strategies are not considered by most people until the last resort, which delays many cancer treatments to advanced stages. Tumor marker sensors show great potential for warning cancer because of cost-effective and harmless checking procedures. Normally one tumor......
Agenparl English Educazione Scienza e Tecnologia Social Network

DESIGN AND SCREENING OF SGK1, SRC DUAL INHIBITORS BY PHARMACOPHORE MODEL, MOLECULAR DOCKING, AND MOLECULAR DYNAMICS SIMULATION

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 21 settembre 2020 Serum and glucocorticoid-regulated protein kinase 1 (SGK1) is highly expressed in many tumors that can promote the growth of tumor cells. Sarcoma gene (Src) is a class of oncogenes, plays an important role in the pathogenesis of cancer, and is an......
Agenparl English Educazione Salute Scienza e Tecnologia Social Network

WHY THE DOSE MATTERS: STUDY SHOWS LEVELS AND ANTI-TUMOR EFFECTIVENESS OF A COMMON DRUG VARY WIDELY

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), gio 17 settembre 2020 When used to manage infections, the drug itraconazole is generally given at a single, fixed dose to all patients. But determining the correct dosage of the drug to help treat cancer isn’t that simple, new research by UT Southwestern suggests. When the......
Agenparl English Salute Scienza e Tecnologia Social Network

WHY THE DOSE MATTERS: STUDY SHOWS THAT LEVELS OF DRUG IN BODY CORRELATE TO ABILITY TO SHRINK TUMORS

Redazione
(AGENPARL) – DALLAS (TEXAS), gio 17 settembre 2020 Above are images of a tumor in the lung of a patient on itraconazole who took part in the study, including a map generated from Dynamic Contrast-Enhanced (DCE) magnetic resonance imaging (right panel). Inset shows the tumor measured for vascular permeability (red......
Agenparl English Educazione Scienza e Tecnologia Social Network

ENGINEERING OF NIR FLUORESCENT PEGYLATED POLY(RGD) PROTEINOID POLYMERS AND NANOPARTICLES FOR DRUG DELIVERY APPLICATIONS IN CHICKEN EMBRYO AND MOUSE MODELS

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mer 16 settembre 2020 Proteinoids are non-toxic biodegradable polymers based on thermal step-growth polymerization of natural or synthetic amino acids. Hollow proteinoid nanoparticles (NPs) may then be formed via a self-assembly process of the proteinoid polymers in an aqueous solution. In the present article polymers......
Agenparl English Educazione Scienza e Tecnologia Social Network

CASCADE DUAL-TARGETED NANOCARRIER FOR ENHANCED ALECTINIB DELIVERY TO ALK-POSITIVE LUNG CANCER

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mer 16 settembre 2020 Alectinib is a highly efficacious inhibitor for the treatment of anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) in the clinic; however, serious adverse events (AEs) occurred in 44.0% of patients. Herein, we explored magnetic/TAT dual-targeted nanocarriers as delivery systems......
Agenparl English Educazione Scienza e Tecnologia Social Network

NIR-ACTIVATED POLYMERIC NANOPLATFORM WITH ROS- AND TEMPERATURE-SENSITIVE FOR COMBINED PHOTOTHERMAL AND CHEMOTHERAPY ON PANCREATIC CANCER

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 14 settembre 2020 Nanomedicne has attracted growing attentions due to its designability and functionality, as well as its excellent pharmacokinetics with limited side effect, and recently, combined therapies are desirable as they can abtain enhanced therapeutic efficacy using nanomedicine. Herein, we have reported a......
Agenparl English Educazione Salute Scienza e Tecnologia Social Network

FEEDING OFF FUSION OR THE IMMORTALIZATION OF TUMOR CELLS

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), ven 11 settembre 2020 IMAGE: image illustrating the mitochondrial fusion of the Drosophila tumor cells in red, blue staining showing tumor cell nuclei. view more  Credit: ©Knoblich lab/IMBA Worldwide, cancer is the second leading cause of death – in 2018 alone, it claimed approximately 9.6 million lives,......
Agenparl English Educazione Scienza e Tecnologia Social Network

CASCADE REACTION MEDIATED EFFICIENT FERROPTOSIS SYNERGIZES WITH IMMUNOMODULATION FOR HIGH-PERFORMANCE CANCER THERAPY

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), ven 11 settembre 2020 Given that traditional anticancer therapies fail to significantly improve the prognoses, new modalities with high efficiency are urgently needed. Herein, a nanozyme-based formulation, which synergized efficient ferroptosis with immunomodulation for high-performance cancer therapy, was constructed. Specifically, ultrasmall CaO2 and Fe3O4 nanoparticles......
Agenparl English Educazione Scienza e Tecnologia Social Network

A SIMPLE SELF-ADJUVANTING BIOMIMETIC NANOVACCINE SELF-ASSEMBLED WITH THE CONJUGATE OF PHOSPHOLIPIDS AND NUCLEOTIDES CAN INDUCE STRONG CANCER IMMUNOTHERAPEUTIC EFFECT

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), ven 11 settembre 2020 Biomimetic nanoparticles have potential applications in many fields for their favorable properties. Here, we developed a self-adjuvanting biomimetic anti-tumor nanovaccine, which was self-assembled with an amphiphilic conjugate synthetized with phospholipids of 1, 2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) and hydrophilic Toll-like receptor (TLR9) agonists CpG......

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