Agenparl

residues

Agenparl English Educazione Scienza e Tecnologia Social Network

MEMBRANE ELECTROSTATICS SENSED BY TRYPTOPHAN ANCHORS IN HYDROPHOBIC MODEL PEPTIDES DEPENDS ON NON-AROMATIC INTERFACIAL AMINO ACIDS: IMPLICATIONS IN HYDROPHOBIC MISMATCH

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 21 settembre 2020 WALPs are synthetic α-helical membrane-spanning peptides that constitute a well-studied system for exploring hydrophobic mismatch. These peptides represent a simplified consensus motif for transmembrane domains of intrinsic membrane proteins due to their hydrophobic core of alternating leucine and alanine flanked by......
Agenparl English Educazione Scienza e Tecnologia Social Network

ON THE PROPAGATION OF THE OH RADICAL PRODUCED BY CU-AMYLOID BETA PEPTIDE MODEL COMPLEXES. INSIGHT FROM MOLECULAR MODELLING.

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), gio 17 settembre 2020 Oxidative stress and metal dyshomeostasis are considered crucial factors in the pathogenesis of the Alzheimer’s disease (AD). Indeed, transition metal ions such as Cu(II) can generate Reactive Oxygen Species (ROS) via O2 Fenton-like reduction, catalyzed by Cu(II) coordinated to the Amyloid......
Agenparl English Educazione Scienza e Tecnologia Social Network

COMPARATIVE STUDY OF GOLD AND SILVER INTERACTIONS WITH AMINO ACIDS AND NUCLEOBASES

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mar 15 settembre 2020 Metal nanoclusters (NCs) have gained much attention in the last decade. In solution, metal nanoclusters can be stabilized by proteins, and, thus, exhibit many advantages in biocatalysis, biosensing, and bioimaging. In spite of much progress in the synthesis of polypeptide-stabilized gold......
Agenparl English Agroalimentare Social Network

INDIA: GOVERNMENT OF INDIA PROPOSES AMENDMENTS IN CONTAMINANTS TOXINS AND RESIDUES REGULATION

Redazione
(AGENPARL) – WASHINGTON (DC), dom 13 settembre 2020 The Government of India’s (GOI) Food Safety and Standards Authority of India (FSSAI) proposed amendments in the Food Safety and Standards (Contaminants, Toxins and Residues) Regulations, 2011, to update tolerance limits for various crop contaminants, veterinary drugs and naturally occurring toxic substances.......
Agenparl English Educazione Scienza e Tecnologia Social Network

UNFOLDING TRANSITION STATE OF UBIQUITIN WITH CHARGED RESIDUES HAS HIGHER ENERGY THAN THAT WITH HYDROPHOBIC RESIDUES

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mer 09 settembre 2020 The native-state structure and folding pathways of a protein are encoded in its amino acid sequence. Ubiquitin, a post-translational modifier, primarily noted for its role in intracellular protein degradation, has two salt bridges: one relatively exposed (SB1:K11-E34) and the other relatively......
Agenparl English Educazione Scienza e Tecnologia Social Network

CATALYSIS BY THE JMJC HISTONE DEMETHYLASE KDM4A INTEGRATES SUBSTRATE DYNAMICS, CORRELATED MOTIONS AND MOLECULAR ORBITAL CONTROL

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), ven 04 settembre 2020 The Nξ-methyl lysine status of histones is important in the regulation of eukaryotic transcription. The Fe(II) and 2-oxoglutarate (2OG) – dependent JmjC domain enzymes are the largest family of histone Nξ-methyl lysine demethylases (KDMs). The human KDM4 subfamily of JmjC KDMs......
Agenparl English Educazione Scienza e Tecnologia Social Network

UNVEILING CONFORMATIONAL DYNAMICS CHANGES OF H-RAS INDUCED BY MUTATIONS BASED ON ACCELERATED MOLECULAR DYNAMICS

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mer 26 agosto 2020 It is of high significance for understanding Ras signaling to uncover molecular basis with regard to conformational change of two switches Ⅰ and Ⅱ in the GppNHp (GNP)-bound H-Ras. For this aim, accelerated molecular dynamics (aMD) simulations and principal component (PC)......

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