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proteins

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ENGINEERED BACTERIA CHURN OUT CANCER BIOMARKERS

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), gio 17 settembre 2020 Pity the glycan. These complex sugar molecules are attached to 80% of the proteins in the human body, making them an essential ingredient of life. But this process, known as glycosylation, has been somewhat overshadowed by flashier biomolecular processes such as transcription......
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MECHANISM DISCOVERED HOW THE CORONAVIRUS HIJACKS THE CELL

Redazione
(AGENPARL) – ZURICH (SWITZERLAND) lun 14 settembre 2020 Like a pirate hijacking a ship, a virus takes control of an infected cell because every virus depends on the resources and molecular machines of the cell to multiply. This also applies to SARS-CoV-2, the causative agent of the COVID-19 pandemic. Researchers......
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FAST PROTEIN ANALYSIS ENABLED BY HIGH-TEMPERATURE HYDROLYSIS

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), gio 10 settembre 2020 While the bottom-up protein analysis serves as a mainstream method for biological studies, its efficiency is limited by the time-consuming process for enzymatic digestion or hydrolysis as well as the post-digestion treatment prior to mass spectrometry analysis. In this work, we......
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FINDING A HANDLE TO BAG THE RIGHT PROTEINS

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), mer 09 settembre 2020 Purifying specific protein molecules from complex mixtures will become easier with a simpler way to detect a molecular “tag” commonly used as a handle to grab the proteins. Proteins, comprising many linked amino acid molecules, form the key “workforce” of molecular biology,......
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DESIGNED ANTIVIRAL PROTEINS INHIBIT SARS-COV-2 IN THE LAB

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), mer 09 settembre 2020 Computer-designed small proteins have now been shown to protect lab-grown human cells from SARS-CoV-2, the coronavirus that causes COVID-19. The findings are reported today, Sept. 9, in Science In the experiments, the lead antiviral candidate, named LCB1, rivaled the best-known SARS-CoV-2 neutralizing......
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PREDICTION OF PROTEIN DISORDER FROM AMINO ACID SEQUENCE

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), mer 09 settembre 2020 (Aarhus University) Structural disorder is vital for proteins’ function in diverse biological processes. It is therefore highly desirable to be able to predict the degree of order and disorder from amino acid sequence. Researchers from Aarhus University have developed a prediction tool......
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A MASS SPECTROMETRY-BASED APPROACH GIVES NEW INSIGHT TO ORGANOTIN-PROTEIN INTERACTIONS

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mer 09 settembre 2020 In this study, the combination of speciation analysis and native mass spectrometry is presented as a powerful tool to gain new insight into the diverse interactions of environmentally relevant organotin compounds (OTCs) with proteins. Analytical standards of model proteins, such as......
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THE ART OF WAR: HOW BACTERIA GATHER INTEL FOR GUIDING THEIR CRISPR-CAS SYSTEMS

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), mar 08 settembre 2020 IMAGE: The CRISPR-Cas systems of T. thermophilus HB27c and spacer acquisition in phiFa phage infected culture. view more  Credit: Daria Artamonova et al./Nucleic Acids Research Researchers from the Severinov Lab at Skoltech have looked at how a poorly studied type of CRISPR-Cas defense......
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INVESTIGATIONAL DRUG STOPS TOXIC PROTEINS TIED TO NEURODEGENERATIVE DISEASES

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), mar 08 settembre 2020 An investigational drug that targets an instigator of the TDP-43 protein, a well-known hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), may reduce the protein’s buildup and neurological decline associated with these disorders, suggests a pre-clinical study from researchers at......
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STABILIZATION OF PROTEINS EMBEDDED IN SUGARS AND WATER AS STUDIED BY DIELECTRIC SPECTROSCOPY

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mar 08 settembre 2020 In many products proteins have become an important component, and the long-time properties of these products are directly dependent on the stability of their proteins. To enhance this stability it has become common to add disaccharides in general, and trehalose in......

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