Agenparl

inhibitors

Agenparl English Educazione Scienza e Tecnologia Social Network

STUDY ON INHIBITORS FROM ACID PRETREATMENT OF CORN STALK ON ETHANOL FERMENTATION BY ALCOHOL YEAST

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 19 ottobre 2020 The inhibitory effects of the main inhibitors formed during acid pretreatment of corn stalk were studied through ethanol fermentations of model substrates and hydrolysates from corn stalk by alcohol yeast. Experimental results showed that the tested inhibitors had no significant effect......
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CORROSION INHIBITION OF CARBON STEEL IN HYDROCHLORIC ACID SOLUTION USING NEWLY SYNTHESIZED UREA-BASED CATIONIC FLUOROSURFACTANTS: EXPERIMENTAL AND COMPUTATIONAL INVESTIGATIONS

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 28 settembre 2020 The facile synthesis approach, surface-active properties, and anti-corrosive efficiency of innovative urea-based cationic fluorinated surfactants (FUS) of variable alkyl chain length are investigated. The effect of as-prepared FUS inhibitors on the carbon steel corrosion in 15% HCl solution at 20-50 °C......
Agenparl English Educazione Scienza e Tecnologia Social Network

EXPLORING INDOLE DERIVATIVES AS MYELOID CELL LEUKAEMIA-1 (MCL-1) INHIBITORS WITH MULTI-QSAR APPROACH: A NOVEL HOPE IN ANTI-CANCER DRUG DISCOVERY

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 21 settembre 2020 In human, the over-expression of Mcl-1 protein causes the different cancers and it is also responsible for cancer resistance to different cytotoxic agents. Thus, discovery of potential inhibitors of Mcl-1 is very important and both pharmaceutical industry and academia are looking......
Agenparl English Educazione Scienza e Tecnologia Social Network

DISCOVERY OF ANTHOCYANINS FROM CRANBERRY EXTRACT AS PANCREATIC LIPASE INHIBITORS USING A COMBINED APPROACH OF ULTRAFILTRATION, MOLECULAR SIMULATION AND SPECTROSCOPY

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 07 settembre 2020 Obesity is a chronic disease that has been causing serious problems all over the world. However, there is a lack of available therapeutic approach to treat obesity. The FDA-approved drug orlistat has severe side effects, such as abdominal pain, flatulence and......
Agenparl English Educazione Salute Scienza e Tecnologia Social Network

SCIENTISTS DEVELOP FIRST DRUG-LIKE COMPOUNDS TO INHIBIT ELUSIVE CANCER-LINKED ENZYMES

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), lun 31 agosto 2020 A team of scientists from the University of Michigan Rogel Cancer Center has developed the first drug-like compounds to inhibit a key family of enzymes whose malfunction is associated with several types of cancer, including an aggressive form of childhood leukemia. The......
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ELABORATING PIPERAZINYL-FUROPYRIMIDINE BASED SCAFFOLDS AS PHOSPHOINOSITOL-3-KINASE ENZYME ALPHA (PI3Kα) INHIBITORS TO COMBAT PANCREATIC CANCER

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), ven 28 agosto 2020 Phosphoinositol-3-kinase enzyme (PI3K) plays a crucial role in driving oncogenic growth in various mammalian cells, particularly pancreatic cells. In the current study a series of novel furo[2,3-d]pyrimidine based-compounds were designed and synthesized as potential PI3K-α inhibitors. In accordance to the structure–activity......
Agenparl English Educazione Scienza e Tecnologia Social Network

DISCOVERY OF MERCAPTOPROPANAMIDE-SUBSTITUTED ARYL TETRAZOLES AS NEW BROAD-SPECTRUM METALLO-β-LACTAMASE INHIBITORS

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mar 25 agosto 2020 β-Lactam antibiotic resistance mediated by metallo-β-lactamases (MBL) has threatened global public health. There are currently no available inhibitors of MBLs for clinical use. We previously reported the ruthenium-catalyzed meta-selective C–H nitration synthesis method, leading to some meta-mercaptopropanamide substituted aryl tetrazoles as......
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PENTACYCLIC TRITERPENOID ACIDS IN STYRAX AS POTENT AND HIGHLY SPECIFIC INHIBITORS AGAINST HUMAN CARBOXYLESTERASE 1A

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), ven 21 agosto 2020 Human carboxylesterase 1A1 (hCES1A) is a promising target for the treatment of hyperlipidemia and obesity-associated metabolic diseases. Until now, the highly specific and efficacious hCES1A inhibitors are rarely reported. This study aims to find potent and highly specific hCES1A inhibitors from......
Agenparl English Educazione Scienza e Tecnologia Social Network

MECHANISM STUDY FOR ABNORMAL ACCUMULATION AND DEPOSITION OF ISLET AMYLOID POLYPEPTIDE BY COLD-SPRAY IONIZATION MASS SPECTROMETRY

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), gio 20 agosto 2020 The abnormal accumulation and deposition of islet amyloid polypeptide (IAPP) are important causes of type 2 diabetes mellitus (T2DM). The common anti-amyloid strategy is that employ inhibitors to prevent the oligomers formation and the cytotoxicity caused by them, thus reducing the......
Agenparl English Educazione Scienza e Tecnologia Social Network

UNDERSTANDING THE ROLE OF GALECTIN INHIBITORS AS POTENTIAL CANDIDATES FOR SARS-COV-2 SPIKE PROTEIN: IN SILICO STUDIES

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), gio 13 agosto 2020 The Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has been rapidly transmitting and leaving its footprints across the globe. Stringent measures like complete lockdown and extensive testing have been employed by many countries to slow it down in its tracks......

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