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PROTECTIVE EFFECTS OF GANODERMA ATRUM POLYSACCHARIDE AGAINST ACRYLAMIDE-INDUCED INFLAMMATION AND OXIDATIVE DAMAGE IN RATS

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 30 novembre 2020 In this study, the protective effects of Ganoderma atrum polysaccharide (PSG-1) on selected tissue (liver, spleen, kidney and intestine) toxicity induced by acrylamide (AA) in SD rats were investigated. The results showed that pretreatment of PSG-1 could prevent the AA-induced damage......
Agenparl English Educazione Scienza e Tecnologia Social Network

EXPOSURE TO A COMBINATION OF SILICA NANOPARTICLES AND LOW-DOSE RADIATION AGGRAVATES LUNG FIBROSIS IN MICE VIA GUT MICROBIOTA MODULATION

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), sab 28 novembre 2020 Exposure to silica nanoparticles (SNPs) causes lung fibrosis and threatens human health. However, it is unknown if low-dose radiation (LDR) exposure exacerbates SNP-induced lung dysfunction. Thus, the aim of our study was to determine the combined effect of SNPs and LDR......
Agenparl English Educazione Scienza e Tecnologia Social Network

POTENTIAL ROLES OF DIETARY FLAVONOIDS FROM CITRUS AURANTIUM L. VAR. AMARA ENGL. IN ATHEROSCLEROSIS DEVELOPMENT

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mer 21 ottobre 2020 Dietary consumption of flavonoids correlated positively with lower risk of cardiovascular disease. However, the precise roles of flavonoids from the blossoms of Citrus aurantium Linn variant amara Engl (CAVA) in atherosclerosis (AS) are still poorly understood. This study aimed to find......
Agenparl English Educazione Scienza e Tecnologia Social Network

NEUROPROTECTIVE EFFECTS OF SOY ISOFLAVONES ON THE CHRONIC ETHANOL-INDUCED DEMENTIA MOUSE MODEL

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), sab 03 ottobre 2020 Chronic ethanol intake can lead to dementia by activating neuroinflammation, causing oxidative stress response, reducing cholinergic function and inducing neuronal apoptosis. Soy isoflavones (SI) exert beneficial effects in a variety of neurodegenerative disorders by acting on the anti-inflammatory, anti-oxidant, anti-apoptotic and......
Agenparl English Educazione Scienza e Tecnologia Social Network

TCD, A TRITERPENOID ISOLATED FROM WILD BITTER GOURD, REDUCES SYNAPTOSOMAL RELEASE OF GLUTAMATE AND PROTECTS AGAINST KAINIC ACID-INDUCED NEURONAL DEATH

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 28 settembre 2020 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al (TCD) is a triterpenoid isolated from wild bitter gourd that is a common tropical vegetable with neuroprotective effects. Because excessive glutamate release is a major cause of neuronal damage in various neurological disorders, the aims of this study were to......
Agenparl English Educazione Scienza e Tecnologia Social Network

VELVET ANTLER POLYPEPTIDE PREVENTS DISRUPTION OF HEPATIC TIGHT JUNCTION VIA INHIBITING OXIDATIVE STRESS IN CHOLESTASIS MICE AND LIVER CELL LINES

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 28 settembre 2020 The aim of the present study was to examine the protective effects and mechanism of velvet antler polypeptide (VAP) against lithocholic acid (LCA)-induced cholestatic liver injury in mice. A 7.0 kDa VAP was orally administered at doses of 10 and 20......
Agenparl English Educazione Scienza e Tecnologia Social Network

ISOLATION AND IDENTIFICATION OF BIOACTIVE PEPTIDES FROM XUANWEI HAMS RESCUING THE OXIDATIVE STRESS DAMAGE INDUCED BY ALCOHOL IN HHL-5 HEPATOCYTES

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 28 settembre 2020 Peptides extracted from Xuanwei ham (XHP) can prevent free radical-induced diseases. The aim of the present study was to isolate and identify bioactive peptides from Xuanwei hams rescuing the oxidative stress damage induced by alcohol in HHL-5 hepatocytes. Alcohol treated HHL-5......
Agenparl English Educazione Scienza e Tecnologia Social Network

MANGIFERIN PROTECTS AGAINST ALCOHOLIC LIVER INJURY VIA SUPPRESSION OF INFLAMMATION-INDUCED ADIPOSE HYPERLIPOLYSIS

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), gio 24 settembre 2020 Adipose dysfunction is closely associated with alcoholic liver disease. The impact of mangiferin on ethanol-induced liver injury and the probable underlying molecular mechanism has not been sufficiently addressed. In the present study, mice were subjected to a chronic plus a single......
Agenparl English Educazione Scienza e Tecnologia Social Network

MONOISOAMYL DMSA REDUCED COPPER-INDUCED NEUROTOXICITY BY LOWERING 8-OHDG LEVEL, AMYLOID BETA AND TAU PROTEIN EXPRESSIONS IN SPRAGUE-DAWLEY RATS

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mer 23 settembre 2020 Introduction: copper dyshomeostasis has long been linked with several neurodegenerative disorders. The binding of Cu with amyloid beta and other neuronal proteins in the brain leads to the generation of oxidative stress, which eventually causes neurotoxicity. Method: the present study was......
Agenparl English Educazione Scienza e Tecnologia Social Network

ANTI-INFLAMMATORY AND ANTI-NOCICEPTIVE ACTIVITIES OF INDIGO THROUGH REGULATING IKKβ/IκB/NF-κB PATHWAY IN MICE

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), ven 18 settembre 2020 This study was to investigate the anti-inflammatory and anti-nociceptive activities of indigo in mice and to explore the possible related mechanisms. Xylene-induced ear edema, carrageenan-induced paw edema and acetic acid-induced vascular permeability test were used to investigate the anti-inflammatory activities of......

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