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PHENOTYPE-RELATED DRUG SENSITIVITY ANALYSIS OF SINGLE CTCS FOR MEDICINE EVALUATION

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 10 agosto 2020 Due to the heterogeneous and variable drug sensitivity of tumor cells, real-time monitoring of a patient’s drug response is desirable for implementing personalized and dynamic therapy. Although considerable efforts have been directed at drug screening in living cells, performing repeated drug......
Agenparl English Educazione Salute Scienza e Tecnologia Social Network

NEW TREATMENT TARGETS FOUND FOR BLINDING RETINAL DISEASE

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), lun 10 agosto 2020 IMAGE: Drs. Ruth Caldwell, Yuqing Huo and Zhiping Liu. view more  Credit: Phil Jones, Senior Photographer, Augusta University When the eye isn’t getting enough oxygen in the face of common conditions like premature birth or diabetes, it sets in motion a state of......
Agenparl English Salute Scienza e Tecnologia Social Network

PINPOINTING THE CELLS THAT KEEP THE BODY’S MASTER CIRCADIAN CLOCK TICKING

Redazione
(AGENPARL) – DALLAS (TEXAS), ven 07 agosto 2020 The image represents the in vivo bioluminescence of a new mouse line that is red unless genetically converted to green bioluminescence as seen in the head between the eyes. Digital artwork by Fernando Augusto.Credit: Neuron DALLAS – Aug. 7, 2020 – UT Southwestern scientists......
Agenparl English Educazione Salute Scienza e Tecnologia Social Network

NSD2 ENZYME APPEARS TO PREVENT CELLULAR SENESCENCE

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), ven 07 agosto 2020 (Kumamoto University) Using comprehensive genetic analysis, Kumamoto University researchers have found, for the first time, that the NSD2 enzyme blocks cell aging. Inhibition of NSD2 function in normal cells leads to rapid senescence of cells and the amount of NSD2 in senescent......
Agenparl English Educazione Scienza e Tecnologia Social Network

TARGETED AND DIRECT INTRACELLULAR DELIVERY OF NATIVE DNAZYMES ENABLES HIGHLY SPECIFIC GENE SILENCING

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), ven 07 agosto 2020 DNAzymes exhibit high potentials as gene silencing agents for therapeutic applications. Such purposes, however, are significantly challenged by the targeted and successful delivery of unmodified DNAzymes into cells with minimal side effects. Here, we set out to formulate and demonstrate a......
Agenparl English Educazione Salute Scienza e Tecnologia Social Network

TRAINING NEURAL CIRCUITS EARLY IN DEVELOPMENT IMPROVES RESPONSE

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), ven 07 agosto 2020 When it comes to training neural circuits for tissue engineering or biomedical applications, a new study suggests a key parameter: Train them young. Techniques for training engineered neural circuits usually involve training them after the cells have fully matured. Using light-sensitive neurons......
Agenparl English Educazione Salute Scienza e Tecnologia Social Network

TRAINING NEURAL CIRCUITS EARLY IN DEVELOPMENT IMPROVES RESPONSE, STUDY FINDS

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), gio 06 agosto 2020 CHAMPAIGN, Ill. — When it comes to training neural circuits for tissue engineering or biomedical applications, a new study suggests a key parameter: Train them young. Techniques for training engineered neural circuits usually involve training them after the cells have fully matured.......
Agenparl English Educazione Scienza e Tecnologia Social Network

SIZE EFFECT OF HUMAN EPIDERMAL GROWTH FACTOR-CONJUGATED POLYSTYRENE PARTICLES ON CELL PROLIFERATION

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), gio 06 agosto 2020 Conjugation of growth factors to a carrier is a favorable method to improve their efficacy as therapeutic molecules. Here, we report the carrier size effect on bioactivity of human epidermal growth factor (hEGF) conjugated to polystyrene particles. BALB/3T3 cells were treated......
Agenparl English Educazione Scienza e Tecnologia Social Network

GENE EXPRESSION PROFILING OF COPPER-RESISTANT CACO-2 CLONES

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), gio 06 agosto 2020 The Caco-2 cell line is composed of a heterogeneous mix of cells; isolation of individual clonal populations from this mix allows for specific mechanisms and phenotypes to be further explored. Previously we exposed Caco-2 cells to inorganic copper sulphate or organic......
Agenparl English Educazione Salute Scienza e Tecnologia Social Network

HOW CELLS KEEP GROWING EVEN WHEN UNDER ATTACK

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), gio 06 agosto 2020 IMAGE: Biochemist Peter Chien, reports on recent experiments and discovery about how bacteria switch gears to respond to different stresses but still maintain normal cell functions like DNA replication, in Molecular… view more  Credit: UMass Amherst AMHERST, Mass. – In an unexpected new......

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