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Thursday, 28 August 2025
SITUATION REPORT
Multi-country outbreak of mpox:
External situation report #57 – 28 August 2025
Overview
This is the 57th situation report for the multi-country outbreak of mpox, which provides details on the global epidemiological situation for mpox, including an update on the epidemiological situation for mpox in Africa, with data on the global situation as of 31 July 2025, in Africa as of 17 August and the operational response updates as of 20 August 2025.
Highlights
• All clades of monkeypox virus (MPXV) continue to circulate in several countries. When mpox outbreaks are not rapidly contained and human-to-human transmission is not interrupted, they continue to pose a risk of sustained community transmission. Since the last edition of this report, one country, Senegal, has reported mpox for the first time. Efforts to identify the clade are underway.
• Furthermore, Türkiye has reported cases of mpox due to clade Ib MPXV for the first time and the Democratic Republic of Congo has reported its first cases of mpox due to clade IIb MPXV.
• In July 2025, 47 countries in five (out of six) WHO regions reported a total of 3924 confirmed cases, including 30 deaths (case fatality ratio [CFR] 0.8%). The South-East Asian and Western Pacific regions reported an increase in cases in July 2025, while the African Region, European Region and the Region of the Americas reported a decrease. The Eastern Mediterranean Region did not report any mpox case in July 2025.
• Twenty-one countries in Africa have reported ongoing mpox transmission in the past six weeks. Clade IIb MPXV continues to be reported in West Africa, while Central African countries report both clade Ia and clade Ib MPXV, and East African countries report clade Ib MPXV.
• The recent overall downward trend of confirmed cases across the continent is driven by the decline in cases in the Democratic Republic of the Congo, Sierra Leone and Uganda.
• Kenya continues to experience community transmission and has been observing a gradual upward trend in confirmed cases reported throughout 2025. Cases continue to be reported primarily among young adults, and all but one death have been reported among people living with HIV.
• China, Germany, Türkiye, and the United Kingdom have reported additional cases of mpox due to clade Ib MPXV since the last situation report. These cases have been linked to travel, and community transmission of clade Ib MPXV continues to be reported only in countries in central and eastern Africa.
• On 20 August 2025, the WHO Director-General extended standing recommendations for mpox issued to States Parties by 12 months, until 20 August 2026, to further prevent or reduce international spread of mpox, as well as its impact on health.
Read the full report: https://www.who.int/publications/m/item/multi-country-outbreak-of-mpox–external-situation-report–57—28-august-2025
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