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The interactions of an Aβ protofibril with a cholesterol-enriched membrane and involvement of neuroprotective carbazolium-based substances

(AGENPARL) – London (United Kingdom), mer 15 maggio 2019

Phys. Chem. Chem. Phys., 2019, Advance Article
DOI: D, Paper
Hedayat Karimi, Maryam Heydari Dokoohaki, Amin Reza Zolghadr, Mohammad Hadi Ghatee
The molecular dynamics simulations indicate that the cholesterol content of the membrane could not play a substantial role in the emergence of Alzheimer’s disease. However, the strong interactions between the polar residue of Aβ and the POPC molecules lead to a large perturbation on the membrane bilayer. The simulation results disclose the neuroprotective property of P molecule.
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Fonte/Source: http://feeds.rsc.org/~r/rss/CP/~3/5wX2_cDAeno/C9CP00859D

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