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POLY-γ-GLUTAMIC ACID DERIVED NANOPOLYPLEXES FOR UP-REGULATION OF GAMMA-GLUTAMYL TRANSPEPTIDASE TO AUGMENT TUMOR ACTIVE TARGETING AND ENHANCE SYNERGISTIC ANTITUMOR THERAPY BY REGULATING INTRACELLULAR REDOX HOMEOSTASIS

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), gio 10 settembre 2020 Active targeting strategy had achieved inspiring progress for drug accumulation in tumor therapy, however, the insufficient expression level of many potential receptors posed challenges for drug delivery. Poly-γ-glutamic acid (γ-pGluA), a naturally occurring anionic biopolymer, showed high affinity with Tumor-associated gamma-glutamyl......

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