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NUCLEAR-TARGETED NANOCARRIERS BASED ON PH-SENSITIVE AMPHIPHILES FOR ENHANCED GNA002 DELIVERY AND CHEMOTHERAPY

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 25 gennaio 2021 GNA002, a novel EZH2 inhibitor, exhibits significant anticancer efficiency in solid malignant tumor therapy; however, its poor water solubility and low enrichment at tumor sites limit its clinical application and translation. In this study, an original pH-sensitive nanocarrier (cyclo (RGDyCSH) (cRGD)-poly......

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