Agenparl

acids

Agenparl English Educazione Social Network

INSPIRED BY SUDOKU, U OF T RESEARCHERS CREATE NOVEL PROTEIN-FOLDING ALGORITHM FOR DRUG DISCOVERY

Redazione
(AGENPARL) – TORONTO (ONTARIO – CANADA), sab 03 ottobre 2020 Computational biologists at the University of Toronto’s Donnelly Centre for Cellular and Biomolecular Research have developed an artificial intelligence algorithm that has the potential to create novel protein molecules as finely tuned therapeutics. The team led by Philip M. Kim, a professor......
Agenparl English Educazione Scienza e Tecnologia Social Network

UNIQUE PATHWAY TO PLATFORM CHEMICALS – ALDARIC ACIDS AS STABLE INTERMEDIATES FOR SYNTHESIS OF FURANDICARBOXYLIC ACID ESTERS

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), lun 24 agosto 2020 2,5-Furandicarboxylic acid (FDCA) has received attention as an emerging bio-based building block with many applications, especially in renewable polyesters. The common route to FDCA uses the unstable 5-hydroxymethylfurfural (HMF) as intermediate. Here, we present an alternative route to FDCA and its......
Agenparl English Educazione Scienza e Tecnologia Social Network

DIVERSITY-ORIENTED SYNTHESIS OF PEPTIDE-BORONIC ACIDS BY A VERSATILE BUILDING-BLOCK APPROACH

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), ven 21 agosto 2020 A new strategy for the synthesis of peptide-boronic acids (PBAs) is presented. 20 Fmoc-protected natural amino acids with orthogonal side chain protection were straightforwardly converted into their corresponding boron analogues in three simple steps. Subsequent immobilisation on commercially available 1-glycerol polystyrene......
Agenparl English Educazione Scienza e Tecnologia Social Network

EXPLORING THE PROPERTIES AND POTENTIAL BIOMEDICAL APPLICATIONS OF NSAID-CAPPED PEPTIDE HYDROGELS

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), gio 13 agosto 2020 The development of strategies to minimise the adverse side-effects of non-steroidal anti-inflammatory drugs (NSAIDs) remains a challenge for medicinal chemists. One such strategy is the development of NSAID–peptide prodrug conjugates and this conjugation to a peptide often confers the additional property......
Agenparl English Diritto & Giustizia Salute Social Network

HUMAN MEDICINES EUROPEAN PUBLIC ASSESSMENT REPORT (EPAR): ORPHACOL, CHOLIC ACID, DIGESTIVE SYSTEM DISEASES,METABOLISM, INBORN ERRORS, DATE OF AUTHORISATION: 12/09/2013, DATE OF REFUSAL: 25/05/2012, REVISION: 9, STATUS: AUTHORISED

Redazione
(AGENPARL) – LONDON (UNITED KINGDOM), mar 11 agosto 2020 Orphacol is a medicine containing cholic acid, a substance found in the bile, which is used to digest fats. It is used to treat adults and children from one month of age who have a genetic abnormality that makes them unable......
Agenparl English Educazione Salute Scienza e Tecnologia Social Network

MAMMAL CELLS COULD STRUGGLE TO FIGHT SPACE GERMS

Redazione
(AGENPARL) – WORCESTER (MASSACHUSETTS), gio 23 luglio 2020 The immune systems of mammals – including humans – might struggle to detect and respond to germs from other planets, new research suggests. Microorganisms (such as bacteria and viruses) could exist beyond Earth, and there are plans to search for signs of......

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