(AGENPARL) – LONDON (UNITED KINGDOM), mar 08 settembre 2020
The effect of short-term intake of high- and low-concentrations of sucrose solution on the neurochemistry of male and female mice was studied. The body weight, feed intake, sucrose solution consumption and brain monoamine neurotransmitters were determined after 34 days’ intake of 1% and 8% sucrose solutions. The gene expression and protein levels related to dopamine and opioids were also determined. The results showed that the intake of 1% and 8% sucrose solution for 34 days will not cause significant changes in the weight development both of male and female mice. The preference for sucrose varies with sex. Both males and females had greater preference for high concentration of sucrose solution than that of low concentration of sucrose solution. The continuous intake of sucrose stimulated the release of monoamine neurotransmitters (DA, 5-HT, NE) in the brain of mice, and the reward effect of 8% sucrose solution is significantly higher than that of 1% sucrose solution. The sex of mice did not affect the release of neurotransmitters. The gene expressions of D1 and D2 were up-regulated in the 1% sucrose group of male mice, while the OPRM1 gene expression was down-regulated. The expression of these three genes in the 8% sucrose group of male mice was all down-regulated. While the gene expression of D1 and D2 in the 1% and 8% sucrose group (p < 0.05) of female mice were both up-regulated.
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