CONTEXT CONTRIBUTION TO THE INTERMOLECULAR RECOGNITION OF HUMAN ACE2-DERIVED PEPTIDES BY SARS-COV-2 SPIKE PROTEIN: IMPLICATIONS FOR IMPROVING THE PEPTIDE AFFINITY BUT NOT ALTERING THE PEPTIDE SPECIFICITY BY OPTIMIZING INDIRECT READOUT

Mol. Omics, 2020, Advance Article
DOI: 10.1039/D0MO00103A, Research Article

Peng Zhou, Heyi Wang, Zheng Chen, Qian Liu
Disrupting the intermolecular interaction of SARS-CoV-2 S protein with its cell surface receptor hACE2 is a therapeutic strategy against COVID-19. The protein context plays an essential role in hACE α1-helix recognition by viral S protein.
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